Publications

Pastor, V., Hirabayashi, S., Karow, A., Wehrle, J., Kozyra, E. J., Nienhold, R., Ruzaike, G., Lebrecht, D., Yoshimi, A., Niewisch, M., Ripperger, T., Gohring, G., Baumann, I., Schwarz, S., Strahm, B., Flotho, C., Skoda, R. C., Niemeyer, C. M. und Wlodarski, M. W. (2017) «Mutational landscape in children with myelodysplastic syndromes is distinct from adults: specific somatic drivers and novel germline variants», Leukemia, 31(3), S. 759-762. doi: 10.1038/leu.2016.342.   
Suboticki, T., Mitrovic Ajtic, O., Beleslin-Cokic, B. B., Nienhold, R., Diklic, M., Djikic, D., Lekovic, D., Bulat, T., Markovic, D., Gotic, M., Noguchi, C. T., Schechter, A. N., Skoda, R. C. und Cokic, V. P. (2017) «Angiogenic factors are increased in circulating granulocytes and CD34+ cells of myeloproliferative neoplasms», Mol Carcinog, 56(2), S. 567-579. doi: 10.1002/mc.22517.   
Lekovic, D., Gotic, M., Skoda, R., Beleslin-Cokic, B., Milic, N., Mitrovic-Ajtic, O., Nienhold, R., Sefer, D., Suboticki, T., Buac, M., Markovic, D., Diklic, M. und Cokic, V. P. (2017) «Bone marrow microvessel density and plasma angiogenic factors in myeloproliferative neoplasms: clinicopathological and molecular correlations», Ann Hematol, 96(3), S. 393-404. doi: 10.1007/s00277-016-2890-9.   
Grisouard, J., Li, S., Kubovcakova, L., Rao, T. N., Meyer, S. C., Lundberg, P., Hao-Shen, H., Romanet, V., Murakami, M., Radimerski, T., Dirnhofer, S. und Skoda, R. C. (2016) «JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis», Blood, 128(6), S. 839-851. doi: 10.1182/blood-2015-12-689216.   edoc
Theocharides, A. P., Lundberg, P., Lakkaraju, A. K., Lysenko, V., Myburgh, R., Aguzzi, A., Skoda, R. C. und Manz, M. G. (2016) «Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency», Blood, 127(25), S. 3253-3259. doi: 10.1182/blood-2016-02-696310.   edoc
Grisouard, J., Shimizu, T., Duek, A., Kubovcakova, L., Hao-Shen, H., Dirnhofer, S. und Skoda, R. C. (2015) «Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPN», Blood, 125(13), S. 2131-2140. doi: 10.1182/blood-2014-08-594572.   edoc
Karow, A., Nienhold, R., Lundberg, P., Peroni, E., Putti, M. C., Randi, M. L. und Skoda, R. C. (2015) «Mutational profile of childhood myeloproliferative neoplasms», Leukemia, 29(12), S. 2407-2409. doi: 10.1038/leu.2015.205.   edoc
Hammaren, H. M., Ungureanu, D., Grisouard, J., Skoda, R. C., Hubbard, S. R. und Silvennoinen, O. (2015) «ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation», Proceedings of the National Academy of Scince of the U.S.A, 112(15), S. 4642-4647. doi: 10.1073/pnas.1423201112.   edoc
Skoda, R. C., Duek, A. und Grisouard, J. (2015) «Pathogenesis of myeloproliferative neoplasms», Experimental Hematology, 43(8), S. 599-608. doi: 10.1016/j.exphem.2015.06.007.   edoc
Strassel, C., Kubovcakova, L., Mangin, P. H., Ravanat, C., Freund, M., Skoda, R. C., Denis, C. V., Dupuis, A., Herbrecht, R., Gachet, C. und Lanza, F. (2015) «Haemorrhagic and thrombotic diatheses in mouse models with thrombocytosis», Thrombosis and Haemostasis, 113(2), S. 414-425. doi: 10.1160/TH14-08-0667.   edoc
Holbro, A., Skoda, R., Lundberg, P., Passweg, J., Buser, A. und Lehmann, T. (2015) «Erythropoietin receptor mutation--a rush of blood to the head?», Annals of hematology, 94(7), S. 1229-1231. doi: 10.1007/s00277-015-2346-7.   edoc
Hussein, K., Percy, M., McMullin, M. F., Schwarz, J., Schnittger, S., Porret, N., Martinez-Aviles, L. M., Paricio, B. B., Giraudier, S., Skoda, R., Lippert, E., Hermouet, S. und Cario, H. (2014) «Clinical utility gene card for: Hereditary thrombocythemia», European journal of human genetics. Nature Publishing Group, 22(2). doi: 10.1038/ejhg.2013.117.   edoc
Sánchez-Aguilera, A., Arranz, L., Martín-Pérez, D., García-García, A., Stavropoulou, V., Kubovcakova, L., Isern, J., Martín-Salamanca, S., Langa, X., Skoda, R. C., Schwaller, J. und Méndez-Ferrer, S. (2014) «Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis», Cell stem cell, 15(6), S. 791-804. doi: 10.1016/j.stem.2014.11.002.   
Skoda, R. C. (2014) «Less Jak2 makes more platelets», Blood, 124(14), S. 2168-2169. doi: 10.1182/blood-2014-08-596361.   
Santisakultarm, T. P., Paduano, C. Q., Stokol, T., Southard, T. L., Nishimura, N., Skoda, R. C., Olbricht, W. L., Schafer, A. I., Silver, R. T. und Schaffer, C. B. (2014) «Stalled cerebral capillary blood flow in mouse models of essential thrombocythemia and polycythemia vera revealed by in vivo two-photon imaging», J Thromb Haemost, 12(12), S. 2120-2130. doi: 10.1111/jth.12738.   
Grisouard, J., Hao-Shen, H., Dirnhofer, S., Wagner, K. U. und Skoda, R. C. (2014) «Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia», Haematologica, 99(4), S. e52-4. doi: 10.3324/haematol.2013.100016.   
Lundberg, P., Karow, A., Nienhold, R., Looser, R., Hao-Shen, H., Nissen, I., Girsberger, S., Lehmann, T., Passweg, J., Stern, M., Beisel, C., Kralovics, R. und Skoda, R. C. (2014) «Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms», Blood, 123(14), S. 2220-2228. doi: 10.1182/blood-2013-11-537167.   
Lundberg, P., Nienhold, R., Ambrosetti, A., Cervantes, F., Perez-Encinas, M. M. und Skoda, R. C. (2014) «Somatic mutations in calreticulin can be found in pedigrees with familial predisposition to myeloproliferative neoplasms», Blood, 123(17), S. 2744-2745. doi: 10.1182/blood-2014-01-550863.   
Lundberg, P., Takizawa, H., Kubovcakova, L., Guo, G., Hao-Shen, H., Dirnhofer, S., Orkin, S. H., Manz, M. G. und Skoda, R. C. (2014) «Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F», J Exp Med, 211(11), S. 2213-2230. doi: 10.1084/jem.20131371.   
Arranz, L., Sánchez-Aguilera, A., Martín-Pérez, D., Isern, J., Langa, X., Tzankov, A., Lundberg, P., Muntión, S., Tzeng, Y.-S., Lai, D.-M., Schwaller, J., Skoda, R. C. und Méndez-Ferrer, S. (2014) «Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms», Nature, 512(7512), S. 78-81. doi: 10.1038/nature13383.   
Duek, A., Lundberg, P., Shimizu, T., Grisouard, J., Karow, A., Kubovcakova, L., Hao-Shen, H., Dirnhofer, S. und Skoda, R. C. (2014) «Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F-driven mouse model of MPNs», Blood, 123(25), S. 3943-3950. doi: 10.1182/blood-2013-07-514208.   
Grisouard, J., Ojeda-Uribe, M., Looser, R., Hao-Shen, H., Lundberg, P., Duek, A., Jeandidier, E., Karow, A. und Skoda, R. C. (2013) «Complex subclone structure that responds differentially to therapy in a patient with essential thrombocythemia and chronic myeloid leukemia», Blood. American Society of Hematology, 122(22), S. 3694-3696. doi: 10.1182/blood-2013-07-516385.   edoc
Girsberger, S., Karow, A., Lundberg, P., Dirnhofer, S., Lehmann, T., Passweg, J. R., Tichelli, A., Skoda, R. und Rovo, A. (2013) «JAK2 V617F-mutated myeloproliferative neoplasia developing five years after wild-type JAK2 acute myeloid leukemia : a case report», Acta Haematologica. Karger, 129(1), S. 23-25. doi: 10.1159/000342100.   edoc | Open Access
Kubovcakova, L., Lundberg, P., Grisouard, J., Hao-Shen, H., Romanet, V., Andraos, R., Murakami, M., Dirnhofer, S., Wagner, K. U., Radimerski, T. und Skoda, R. C. (2013) «Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model», Blood. American Society of Hematology, 121(7), S. 1188-1199. doi: 10.1182/blood-2012-03-415646.   edoc
de Wit, T. D., Borkhardt, A., Chomienne, C., Dohner, H., Fibbe, W. E., Foa, R., Hagenbeek, A., Skoda, R. C., Smand, C. R. und Jager, U. (2012) «Raising hematology’s European voice: the importance of calling yourself a hematologist», Haematologica. Haematologica, 97(4), S. 476-478. doi: 10.3324/haematol.2011.057257.   edoc
Lai, J. C., Ponti, S., Pan, D., Kohler, H., Skoda, R. C., Matthias, P. und Nagamine, Y. (2012) «The DEAH-box helicase RHAU is an essential gene and critical for mouse hematopoiesis», Blood. American Society of Hematology, 119(18), S. 4291-4300. doi: 10.1182/blood-2011-08-362954.   edoc
Schaub, F. X., Lehmann, T., Looser, R., Hao-Shen, H., Tichelli, A. und Skoda, R. C. (2011) «Transition to homozygosity does not appear to provide a clonal advantage to hematopoietic progenitors carrying mutations in TET2», Blood. American Society of Hematology, S. 2075-2076. doi: 10.1182/blood-2010-11-316471.   edoc
Passamonti, F., Elena, C., Schnittger, S., Skoda, R. C., Green, A. R., Girodon, F., Kiladjian, J.-J., McMullin, M. F., Ruggeri, M., Besses, C., Vannucchi, A. M., Lippert, E., Gisslinger, H., Rumi, E., Lehmann, T., Ortmann, C. A., Pietra, D., Pascutto, C., Haferlach, T. und Cazzola, M. (2011) «Molecular and clinical features of the myeloproliferative neoplasm associated with JAK2 exon 12 mutations», Blood. American Society of Hematology, 117(10), S. 2813-2816. doi: 10.1182/blood-2010-11-316810.   edoc
Ungureanu, D., Wu, J., Pekkala, T., Niranjan, Y., Young, C., Jensen, O. N., Xu, C.-F., Neubert, T. A., Skoda, R. C., Hubbard, S. R. und Silvennoinen, O. (2011) «The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling», Nature structural & molecular biology. Nature Publ. Group, 18(9), S. 971-976. doi: 10.1038/nsmb.2099.   edoc
Skoda, R. C. und Schwaller, J. (2011) «HiJAKing the methylosome in myeloproliferative disorders», Cancer cell. Cell Press, 19(2), S. 161-163. doi: 10.1016/j.ccr.2011.01.046.   edoc
Zhang, G., Xiang, B., Dong, A., Skoda, R. C., Daugherty, A., Smyth, S. S., Du, X. und Li, Z. (2011) «Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation», Blood. American Society of Hematology, 118(13), S. 3670-3679. doi: 10.1182/blood-2011-03-341107.   edoc
Chagraoui, H., Kassouf, M., Banerjee, S., Goardon, N., Clark, K., Atzberger, A., Pearce, A. C., Skoda, R. C., Ferguson, D. J. P., Watson, S. P., Vyas, P. und Porcher, C. (2011) «SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis», Blood. American Society of Hematology, 118(3), S. 723-735. doi: 10.1182/blood-2011-01-328765.   edoc
Skoda (2010) «Hereditary myeloproliferative disorders», Haematologica, 95(1), S. 6-8.   edoc
Posthuma, H. L. A., Skoda, R. C., Jacob, F. A., van der Maas, A. P. C., Valk, P. J. M. und Posthuma, E. F. M. (2010) «Hereditary thrombocytosis not as innocent as thought? Development into acute leukemia and myelofibrosis», Blood. American Society of Hematology, 116(17), S. 3375-3376.   edoc
Schaub, F. X., Looser, R., Li, S., Hao-Shen, H., Lehmann, T., Tichelli, A. und Skoda, R. C. (2010) «Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms», Blood. American Society of Hematology, 115(10), S. 2003-2007. doi: 10.1182/blood-2009-09-245381.   edoc
Skoda, R. C. (2010) «JAK2 impairs stem cell function?», Blood. American Society of Hematology, 116(9), S. 1392-1393. doi: 10.1182/blood-2010-06-287318.   edoc
Bertozzi, C. C., Schmaier, A. A., Mericko, P., Hess, P. R., Zou, Z., Chen, M., Chen, C.-Y., Xu, B., Lu, M.- min, Zhou, D., Sebzda, E., Santore, M. T., Merianos, D. J., Stadtfeld, M., Flake, A. W., Graf, T., Skoda, R., Maltzman, J. S., Koretzky, G. A. und Kahn, M. L. (2010) «Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling», Blood. American Society of Hematology, 116(4), S. 661-670. doi: 10.1182/blood-2010-02-270876.   edoc
Olcaydu, D., Skoda, R. C., Looser, R., Li, S., Cazzola, M., Pietra, D., Passamonti, F., Lippert, E., Carillo, S., Girodon, F., Vannucchi, A., Reading, N. S., Prchal, J. T., Ay, C., Pabinger, I., Gisslinger, H. und Kralovics, R. (2009) «The ’GGCC’ haplotype of JAK2 confers susceptibility to JAK2 exon 12 mutation-positive polycythemia vera», Leukemia. Nature Publishing Group, 23(10), S. 1924-1926. doi: 10.1038/leu.2009.110.   edoc
Goldman, J. M., Green, A. R., Holyoake, T., Jamieson, C., Mesa, R., Mughal, T., Pellicano, F., Perrotti, D., Skoda, R. und Vannucchi, A. M. (2009) «Chronic myeloproliferative diseases with and without the Ph chromosome : some unresolved issues», Leukemia. Nature Publishing Group, 23(10), S. 1708-1715. doi: 10.1038/leu.2009.142.   edoc
Tefferi, A., Skoda, R. und Vardiman, J. W. (2009) «Myeloproliferative neoplasms : contemporary diagnosis using histology and genetics», Nature reviews . Clinical oncology. Nature Publishing Group, 6(11), S. 627-637.   edoc